The scientific and regenerative biologics innovation division of 4th State Medical.
BioSignal Sciences advances research, product development, scientific education, and collaboration in regenerative signaling biology — informed by the research and experience of Dr. Jonathan Lakey and a broader network of scientific and clinical collaborators.
Guided by decades of translational regenerative research.
The division's scientific direction reflects a career spanning laboratory science, translational research, and clinical collaboration in regenerative biology.
Dr. Jonathan Lakey is Professor Emeritus of Surgery and Biomedical Engineering at UC Irvine, with more than 520 peer-reviewed publications and 50+ invited book chapters spanning diabetes, islet transplantation, stem cell technologies, and biomaterials. He is co-inventor of the Edmonton Protocol — the landmark treatment for Type-1 diabetes via islet transplantation — and brings advanced expertise in cryopreservation alongside several issued and provisional patents. His entrepreneurial work includes serving as Founder & CSO of a pet stem cell therapy company and co-founding a stem cell banking and disease-differentiation transplant company. Globally recognized for leadership in stem cell and exosome-derived therapeutic products, Dr. Lakey provides the scientific foundation for BioSignal Sciences.
- Academic Appointment
- Professor Emeritus of Surgery & Biomedical Engineering, UC Irvine
- Landmark Contribution
- Co-inventor of the Edmonton Protocol for Type-1 diabetes via islet transplantation
- Publications
- 520+ peer-reviewed publications; 50+ invited book chapters
- Research Focus
- Regenerative biology, secretome science, cryopreservation, biomaterials
- Patents
- Several issued and provisional patents
- Entrepreneurship
- Founder & CSO of a pet stem cell therapy company; co-founder of a stem cell banking and transplant company
- Global Leadership
- Recognized leader in stem cell technologies, including exosome-derived therapeutics
- Role at 4th State
- Scientific Founder guiding BioSignal Sciences research and translation
Disciplined focus across regenerative signaling biology.
Each area represents a field of scientific study and inquiry. Descriptions are educational and are not statements about the composition, safety, or efficacy of any specific product.
Systematic profiling of the collective biomolecules secreted by cells — proteins, lipids, nucleic acids, and vesicular cargo — under defined conditions.
Investigation of membrane-bound nanoparticles as carriers of intercellular signaling cargo and their behavior in defined biological environments.
Analytical characterization of signaling proteins that participate in tissue-response, inflammation modulation, and cellular recruitment pathways.
Study of receptor engagement, intracellular cascades, and downstream cellular behaviors relevant to regenerative biology.
Engineered matrices and delivery systems designed to support retention, presentation, and controlled interaction with target environments.
Process design, control strategies, characterization assays, and quality frameworks aligned with regulated biologic product development.
Where the science is done.
Dedicated laboratory space supporting cell handling, cryopreservation, biosafety cabinet work, and microscopy — the physical foundation for characterization-first regenerative research.
Rigor, characterization, and responsible translation.
Product programs progress through defined stages of scientific and regulatory discipline.
No development advances without disciplined analytical characterization of composition, structure, and biological activity.
Consistent, controlled processes with documented specifications, in-process controls, and release testing frameworks.
Preclinical, mechanistic, and clinical evidence determine which programs progress — not narrative or aspiration.
Scientific claims are constrained to what data, regulatory status, and applicable law permit.
A curated body of scientific work.
Peer-reviewed articles, preclinical and clinical studies, posters, and abstracts. A searchable index is maintained in the Research Library.
Patents and pending applications.
A representative view of intellectual property associated with the division's areas of work. Full schedule and status details are maintained under formal review.
Scientific engagement across meetings and institutions.
Partnering with investigators and institutions.
The division welcomes engagement with academic investigators, clinical research centers, and industry partners aligned with disciplined regenerative science.
- Investigator-initiated research proposals
- Institutional and academic partnerships
- Translational and preclinical study design
- Shared characterization and analytical work
- Scientific education and fellowship engagement
Share the scientific question, proposed study design, institution, and materials or capabilities required. Submissions are reviewed by the scientific team.
Submit a Proposal →Recent updates from the division.
- Research Areas
- 6
- Publications
- 5
- Patents
- —
- Collaborations
- Open