Clinical Case Studies

Observed outcomes across the SCCM topical portfolio.

A curated set of clinical case series across BioSignal's current SCCM formulations — wrinkle, acne, scar, diabetic ulcer, neuropathy, and hair restoration. Cases illustrate observed responses under defined protocols; they are not statements of cleared indications or generalized efficacy.

Case Series

Therapeutic Areas

Published Paper

Documented Outcomes

Yes

Wrinkle Cream at 90 days — clinical case imagery — Case 1 — before (left) and after 90 days (right).

Skin — Anti-Aging

— 01

Wrinkle Cream at 90 days

Duration: 90 days
Protocol: Twice-daily topical SCCM anti-wrinkle serum for 90 days. Measurable improvement observed across 12 parameters of facial skin aging: tone, texture, and elasticity across the full facial surface.
Observed: Case 1 — visible improvement in skin tone, texture, and elasticity following daily topical application only.

74-year-old female — combined protocol — clinical case imagery — Case 2 — before (left) and after 3-month protocol (right).

Skin — Anti-Aging

— 02

74-year-old female — combined protocol

Duration: 3 months
Protocol: Three monthly microneedling sessions with stem cell-derived biosignals complex, combined with daily topical SCCM application between sessions.
Observed: Measurable improvement across all 12 parameters of facial aging, including deep periocular and perioral wrinkles.

Active & inflammatory acne — 30 to 60 days — clinical case imagery — Pre-treatment (left) and 60-day endpoint (right).

Skin — Inflammatory

— 03

Active & inflammatory acne — 30 to 60 days

Duration: 30–60 days
Protocol: Daily topical SCCM Acne Cream. Anti-inflammatory activity targeting active lesions, including severe cystic inflammatory forms, without systemic medication.
Observed: Dramatic reduction in inflammatory acne lesions and visible clearance of active pustular and cystic forms within 30 to 60 days.

Hypertrophic & acne scar remodeling — clinical case imagery — Hypertrophic scar — Day 1 (left) and Day 18 (right).

Skin — Scar Remodeling

— 04

Hypertrophic & acne scar remodeling

Duration: 18–60 days
Protocol: Three dermal-needling treatments, each one month apart, using SCCM cream at time of treatment plus twice-daily skincare between sessions.
Observed: Progressive remodeling of both post-acne and hypertrophic scar tissue observed across a 60-day observation window.

Diabetic foot ulcer — full closure in 36 days — clinical case imagery — Ulcer at initial presentation (top) and Day 36 closure (bottom).

Diabetic Wound Care

— 05

Diabetic foot ulcer — full closure in 36 days

Duration: 36 days
Protocol: Weekly topical application of SCCM Diabetic Wound / Ulcer Serum on a chronic diabetic foot ulcer with associated neuropathy and peripheral vascular compromise.
Observed: Full epithelialization achieved within 36 days across treated cases — including wounds unresponsive to prior standard-of-care regimens.

Neuropathy pilot — 6 patients, 30 days — clinical case imagery — Thermographic assessment of lower-extremity perfusion pattern.

Diabetic Neuropathy

— 06

Neuropathy pilot — 6 patients, 30 days

Duration: 30 days
Protocol: Six adult patients with Type-2 diabetes and moderate progressive neuropathy. SCCM Neuropathy Cream applied to feet following microneedling, twice daily for 30 days.
Observed: 60% reduction in diabetic foot pain and 75% relief in burning / tingling sensation on average across the cohort.

Peer-Reviewed Reference

Am J Biomed Sci & Res. 2024;21(1) — Improvements in Diabetic Neuropathy with Topical Human MSC-CM →

Hair restoration — 57-year-old male, 12 weeks — clinical case imagery — Before (left) and 12 weeks after (right) — 57-year-old male.

Hair Management

— 07

Hair restoration — 57-year-old male, 12 weeks

Duration: 12 weeks
Protocol: Six clinic sessions two weeks apart of 1.0 mm microneedling with SCCM serum applied to scalp. Home protocol: twice-weekly topical SCCM following 0.25 mm dermal stamp, plus three-times-weekly SCCM cream between sessions.
Observed: Visible density improvement across vertex and crown at the 12-week endpoint; no systemic side effects reported.

Hair restoration — 58-year-old male, 12 weeks — clinical case imagery — Progression across four view angles over the 12-week protocol.

Hair Management

— 08

Hair restoration — 58-year-old male, 12 weeks

Duration: 12 weeks
Protocol: Six sessions two weeks apart of 1.0 mm microneedling with SCCM serum applied at the scalp. Home maintenance: twice-weekly topical SCCM following 0.2 mm dermal stamp; three-times-weekly SCCM cream without stamp.
Observed: Density improvement and reduced recession observed at 12-week endpoint. No systemic side effects reported.

Wrinkle — Full Panel: 12/12
Neuropathy — Pain: 60%
Neuropathy — Sensation: 75%
Foot Ulcer: 36d

NoticeCase imagery and outcomes describe individual clinical observations under defined protocols and do not represent statistical claims of safety or efficacy for any specific product. SCCM topical formulations discussed here are not represented as diagnosing, treating, curing, preventing, or mitigating disease. Regulatory status and permitted uses vary by product and jurisdiction. See the Regulatory page and the Research Library for referenced publications.