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Manufacturing Science

All research library entries tagged with Manufacturing Science.

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2024-04-16

Peer-Reviewed Publications

Novel Methods to Preserve Mesenchymal Stem Cells at Low Temperatures

Jonathan R.T. Lakey, PhD, Wenyi Guo, Carolina Bluguerman, Tori Tucker, Michael Alexander, Adrian Mutto · Am J Biomed Sci & Res. 2024;22(1)

Validation of a combinational cryoprotectant strategy using lower-than-conventional concentrations of two permeating agents (DMSO and ethylene glycol) with a stepwise sucrose dilution during recovery. The optimized protocol yielded significantly higher post-thaw MSC viability (~80%) versus conventional DMSO-only approaches, supporting more effective banking of stem cells for downstream therapeutic use.

#Cryopreservation#MSC#Manufacturing

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